2.1 Dosage for Treatment of Major Depressive Disorder . Administer CYMBALTA at a total dose of 40 mg/day to 60 mg/day . Duloxetine hydrochloride is a white to slightly brownish white solid, which is slightly soluble in water. Each capsule contains enteric-coated pellets of 22.4, 33.7, or 67.3 mg of...